Activation of Coagulation and Inflammation in Trauma
Multi-centre, interventional, randomised, un-blinded, parallel controlled trial. The trial will evaluate the effects of early fibrinogen replacement using cryoprecipitate in adults with major traumatic bleeding. https://www.c4ts.qmul.ac.uk/research-programmes/cryostat
E-MAGED is an RCT designed to compare the utility of using direct MRCP versus standard care (USS +/- MRCP) in patients in suspected acute gallstone disease who present to the ED and SEU. https://clinicaltrials.gov/ct2/show/NCT03709030
A multicentre randomised controlled trial assessing the mortality, quality of life, and cost effectiveness of operative rib fixation plus supportive management versus supportive management alone for patients with multiple rib fractures requiring ventilator support. https://www.ndorms.ox.ac.uk/clinical-trials/current-trials-and-studies/orif
This is a mix method research to find out n-depth studies provide an opportunity to understand how crashes occur and, from this understanding, contribute to the development of safer roads and safer vehicles. https://trl.co.uk/projects/road-accident-depth-study-raids
Prospective cohort study of proactive palliative care for hospitalised adults at risk of dying: Evaluation of patient outcomes and hospital costs.
A mixed method study looking at the impact of GPs working in or alongside the ED (GPED) on patient care, the primary care and acute hospital team and the wider urgent care system.
BioAID is a multi-centre research tissue bank to enable observational studies in adult infectious diseases.
The GAinS investigators: application of an integrated immune -omic approach in sepsis
Randomised controlled trial comparing the use of splint vs bandage in wrist buckle fractures in children
Early Cryoprecipitate in major Haemorrhage in Trauma is a randomised open label study to determine whether early administration of cryoprecipitate in bleeding trauma patients is possible .
This project aims to address the question of what the potential harm of handover failures along the emergency care pathway is and what common organisational deficiencies impact upon the reliability and quality of handovers. https://core.ac.uk/download/pdf/36771298.pdf
Pre-hospital randomised assessment of mechanical compression device in cardiac arrest. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61886-9/abstract
Integrated Patient Monitoring in the Emergency Department.
A Simple Cognitive task After a Road Traffic Accident.This research study is designed to investigate the effects of a simple cognitive task (a memory reactivation cue following by playing the computer game "Tetris") on flashbacks and other post-traumatic stress symptoms after a road traffic accident.
Evaluate the reversal of the anticoagulant effects of dabigatran by IV administration of 5.0g idarucizumab in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.
Oral Anticoagulant Agent-associated Bleeding Events Reporting System (ORANGE) is an observational study on current management practices and clinical outcomes of OAC-associated major bleeding events across the UK, in order that we may develop better management strategies for the future and provide a knowledge base for further research.
Research study to find out if the study drug, MP4OX, given together with standard treatment, is safe and effective in treating severely injured trauma patients with haemorrhagic shock.
European Dyspnoea survey in the Emergency Departments.
Ankle sprain injury study using radiological imaging to pre-dict recovery.
Ankle sprain injury study using radiological imaging to pre-dict recovery.
Synthesising a clinical Prognostic Rule of Ankle Injuries in the Emergency Department. This is a cohort study looking at how clinicians might predict which types of ankle sprains and or patient groups have better outcomes.
A multicenter prospective cohort study on the diagnostic accuracy of NeutrophilGelatinase-Associated Lipocalin (NGAL) and Cystatin C for Acute Kidney Injury (AKI) inconsecutive adults admitted from the Emergency Department.
The study aims to assess the adequacy of pain management in patients presenting to the ED with confirmed long bone fracture and/or dislocation isolated to a proximal or distal limb.
AIRWAYS-2 is a randomised trial which is comparing the clinical and cost effectiveness of the i-gel supraglottic airway device with tracheal intubation in the initial airway management of patients who have suffered an out of hospital cardiac arrest (OHCA).
The PARAMEDIC2 trial is looking at whether adrenaline is helpful or harmful in the treatment of cardiac arrest which occurs outside of hospital. Answering this question will help to improve future treatment of people who have a cardiac arrest.
The aim of our study is to develop an understanding of how austerity-driven policies and subsequent system reforms impact and shape ideas and practices of ethical professional conduct.
The 2nd Sprint National Anaesthesia Project: Epidemiology of Critical Care provision after Surgery (SNAP-2: EpiCCS)is an epidemiology study of perioperative risk and outcome, and critical care referral and admission after inpatient surgery in the UK.
The study aims to determine the early clinical features predictive of Herpes simplex virus (HSV) encephalitis to support the development of a predictive tool for HSV encephalitis based on these early clinical features.
Multi-centre randomised controlled trial comparing ambulatory management to standard care ( aspiration +/- standard chest drain insertion) with an observational cohort study of patients not requiring an intervention. https://bmjopenrespres.bmj.com/content/6/1/e000403
Observational cohort study to study and understand the characteristics of patients with acute exacerbations of airway disease (asthma, COPD and overlap) presenting to the ED.
A multi-centre, randomised, double blind, placebo controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage.
A multi-centre, prospective, randomized controlled study to compare outcomes of viscoelastic haemostatic assay (VHA)-guided resuscitation versus optimised conventional coagulation test resuscitation support in haemorrhaging trauma patients.
Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial.
Tranexamic Acid vs placebo in Traumatic brain Injury https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext
Pandemic Influenza Triage in the Emergency Department
We aim to identify the most accurate triage method for predicting severe illness among patients attending the emergency department with suspected pandemic influenza.
Russell, REK & Doggett, T & Pavord, I & Pullinger, Richard & Beer, S & Bafadhel, M. (2016). S68 Copd in the ed: eosinophils, treatment and outcomes, data from the pre-award study. Thorax. 71. A40.2-A41.
Clifton, David & Wong, David & Fleming, Susannah & J. Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2011). Novelty Detection for Identifying Deterioration in Emergency Department Patients. 6936. 220-227
Pullinger, Richard & Wilson, Sarah & Way, Rob & Santos, Mauro & Wong, David & Clifton, David & Birks, Jacqueline & Tarassenko, L. (2016). Implementing an electronic observation and early warning score chart in the emergency department: A feasibility study. European Journal of Emergency Medicine. 24.
Way, R & Warnes, K & Yousefi, S & Beer, S & Santos, M & Wong, David & Wilson, S & Pullinger, Richard & Tarassenko, Lionel. (2014). Paper and electronic early warning scoring systems: review of 6000 patients in the emergency department. International Emergency Nursing. 22. 259-259.
J Wilson, Sarah & Wong, David & Pullinger, Richard & Way, Rob & Clifton, David & Tarassenko, L. (2014). Analysis of a data-fusion system for continuous vital sign monitoring in an emergency department. European Journal of Emergency Medicine. 23
Clifton, David & Wong, David & Clifton, Lei & Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2013). A Large-Scale Clinical Validation of an Integrated Monitoring System in the Emergency Department. Biomedical and Health Informatics, IEEE Journal of Biomedical and Health Informatics. 17. 835-842. 10.1109/JBHI.2012.2234130.
J Wilson, Sarah & Wong, David & Clifton, David & Fleming, Susannah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2012). Track and trigger in an emergency department: An observational evaluation study. Emergency medicine journal 30.
Clifton, David & Wong, David & Fleming, Susannah & J. Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2011). Novelty Detection for Identifying Deterioration in Emergency Department Patients. 6936. 220-227.
Curry, N & Raja, A & Hughes, T & Black, J & Pullinger, Richard & Davenport, Ross & Brohi, Karim & Stanworth, S. (2010). A prospective observational study evaluating changes in coagulation parameters in trauma admissions. 50th Annual Scientific Meeting of the British-Society-for-Haematology, Volume: 149 1010.
Keating, L & Benger, Jonathan & Beetham, Robert & Bateman, S & Veysey, S & Kendall, J & Pullinger, Richard. (2006). The PRIMA Study: Presentation ischaemia-modified albumin in the emergency department. Emergency Medicine Journal 23. 764-8. 10.1136/emj.2006.036269.
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