ABC SEPSIS: Feasibility of 5% Albumin compared with Balanced Crystalloid, as intravenous fluid resuscitation in adult patients with sepsis, presenting as an emergency to hospital. https://www.ed.ac.uk/usher/edinburgh-clinical-trials/our-studies/all-current-studies/abc-sepsis
AIRWAYS-2: AIRWAYS-2 is a randomised trial which is comparing the clinical and cost effectiveness of the i-gel supraglottic airway device with tracheal intubation in the initial airway management of patients who have suffered an out of hospital cardiac arrest (OHCA).https://jamanetwork.com/journals/jama/article-abstract/2698493
ATOMIC 2: The purpose of this study is to assess whether the use of a commonly given antibiotic called Azithromycin can prevent or makes no difference to patients getting worse, otherwise known as disease progression of Novel Coronavirus-Induced Disease 2019 (COVID-19) in people who go to hospital, but who doctors decide there is no need to admit them for treatment.
AUSTERITY IN HEALTHCARE – UK: The aim of our study is to develop an understanding of how austerity-driven policies and subsequent system reforms impact and shape ideas and practices of ethical professional conduct.
BRONCHSTART: Impact of Covid-19 on Respiratory Syncytial Virus Seasonality and Disease Severity in UK Children (BronchStart). https://clinicaltrials.gov/ct2/show/NCT04959734
CAP-IT: Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial. https://jamanetwork.com/journals/jama/article-abstract/2785716
CRYOSTAT : Early Cryoprecipitate in major Haemorrhage in Trauma is a randomised open label study to determine whether early administration of cryoprecipitate in bleeding trauma patients is possible. https://academic.oup.com/bja/article/115/1/76/238264
CRYOSTAT 2: CRYOSTAT-2 will evaluate whether early administration of high-dose cryoprecipitate, in addition to standard major haemorrhage therapy, improves survival from traumatic bleeding.
ECHO: This project aims to address the question of what the potential harm of handover failures along the emergency care pathway is and what common organisational deficiencies impact upon the reliability and quality of handovers. https://core.ac.uk/download/pdf/36771298.pdf
E-FIT: A multi-centre, randomised, double blind, placebo controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage. https://www.nhsbt.nhs.uk/clinical-trials-unit/completed-trials-and-studies/e-fit-1/
ENCEPH UK: The study aims to determine the early clinical features predictive of Herpes simplex virus (HSV) encephalitis to support the development of a predictive tool for HSV encephalitis based on these early clinical features.
EURODEM: European Dyspnoea survey in the Emergency Departments
HISPEC: A national randomised controlled trial exploring the benefits of ambulatory management in patients with pneumothorax due to underlying lung disease.
ICICLE: A case control study of the effectiveness of Q/LAIV versus inactivated influenza vaccine and no vaccine in subjects 2-17 years of age.
IPMED: Integrated Patient Monitoring in the Emergency Department https://www.ncbi.nlm.nih.gov/pubmed/25055312
ITACTIC: A multi-centre, prospective, randomized controlled study to compare outcomes of viscoelastic haemostatic assay (VHA)-guided resuscitation versus optimised conventional coagulation test resuscitation support in haemorrhaging trauma patients. https://pubmed.ncbi.nlm.nih.gov/33048195/
LEAK: A multicenter prospective cohort study on the diagnostic accuracy of NeutrophilGelatinase-Associated Lipocalin (NGAL) and Cystatin C for Acute Kidney Injury (AKI) inconsecutive adults admitted from the Emergency Department.
MP4OX: Research study to find out if the study drug, MP4OX, given together with standard treatment, is safe and effective in treating severely injured trauma patients with haemorrhagic shock. A randomised controlled trial of topical intranasal tranexamic acid versus placebo in patients presenting to the Emergency Department with spontaneous acute epistaxis.
NOPAC: A randomised controlled trial of topical intranasal tranexamic acid versus placebo in patients presenting to the Emergency Department with spontaneous acute epistaxis. https://pubmed.ncbi.nlm.nih.gov/33612282/
ORANGE: Oral Anticoagulant Agent-associated Bleeding Events Reporting System (ORANGE) is an observational study on current management practices and clinical outcomes of OAC-associated major bleeding events across the UK, in order that we may develop better management strategies for the future and provide a knowledge base for further research.
http://www.haematologica.org/content/haematol/103/4/738.full.pdf
PARAMEDIC: Pre-hospital randomised assessment of mechanical compression device in cardiac arrest. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61886-9/abstract.
PARAMEDIC2: The PARAMEDIC2 trial is looking at whether adrenaline is helpful or harmful in the treatment of cardiac arrest which occurs outside of hospital. Answering this question will help to improve future treatment of people who have a cardiac arrest. https://www.nejm.org/doi/full/10.1056/NEJMoa1806842
POEM: The study aims to assess the adequacy of pain management in patients presenting to the ED with confirmed long bone fracture and/or dislocation isolated to a proximal or distal limb.
RAMPP: Multi-centre randomised controlled trial comparing ambulatory management to standard care ( aspiration +/- standard chest drain insertion) with an observational cohort study of patients not requiring an intervention. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31043-6/fulltext
SCARTA: A Simple Cognitive task After a Road Traffic Accident. This research study is designed to investigate the effects of a simple cognitive task (a memory reactivation cue following by playing the computer game "Tetris") on flashbacks and other post-traumatic stress symptoms after a road traffic accident. http://www.ox.ac.uk/news/2017-03-28-tetris-used-prevent-post-traumatic-stress-symptoms
SHED: Subarachnoid Haemorrhage in the Emergency Department (SHED) aims to evaluate different strategies for investigating serious causes of headache. In particular, we are looking carefully at those patients who go on to have a scan of their brain and whether the timing of this affects the need for further investigations. https://ternresearch.co.uk/shed
SNAP-2: The 2nd Sprint National Anaesthesia Project: Epidemiology of Critical Care provision after Surgery (SNAP-2: EpiCCS)is an epidemiology study of perioperative risk and outcome, and critical care referral and admission after inpatient surgery in the UK.
STOP-A-PE: Stopping anticoagulation for isolated or incidental subsegmental pulmonary embolism. https://www.birmingham.ac.uk/research/bctu/trials/renal/stopape/index.aspx
RE-VERSE-AD: Evaluate the reversal of the anticoagulant effects of dabigatran by IV administration of 5.0g idarucizumab in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.
SPRAINED: Synthesising a clinical Prognostic Rule of Ankle Injuries in the Emergency Department. This is a cohort study looking at how clinicians might predict which types of ankle sprains and or patient groups have better outcomes.
The Award Study: The hospitalised acute wheezy adult with airways disease: studying the different characteristics and treatment responses. https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/the-award-study/
