CURRENT RESEARCH PROJECTS
COVID -19 Trials
ATOMIC2 - A multi-centre open-label two-arm randomised superiority clinical trial of Azithromycin versus usual care In Ambulatory COVID-19
https://atomic2.octru.ox.ac.uk/
BIOAID: BioResource in Adult Infectious Diseases (2019-2024) aims to collect biological samples and clinical information from patients who present to hospital with a suspected infectious disease.
https://imperialbrc.nihr.ac.uk/2020/01/28/bioaid/
FALCON: Facilitating AcceLerated Clinical validation Of novel diagnostics for COVID-19. Platform study for the evaluation of diagnostic tests for COVID-19
FALCON — CONDOR Platform (condor-platform.org)
GAINS -2: Genomic Advances in Sepsis Study (Sepsis Immunomics ) The overall aim of this study is to understand how and why some patients have an extreme response to infection in order to improve patient care.
ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK). The study aims to find out how infections affect people and hope to find better ways to diagnose and manage people with the same or similar infections.
https://www.hra.nhs.uk/covid-19-research/approved-covid-19-research/1266000/
PRINCIPLE: Platform Randomised Trial of Interventions against COVID-19 In Older People. Aims to assess effectiveness of trial treatments in for patients aged ≥50 years with comorbidity, and aged ≥65 with or without comorbidity and suspected COVID-19 infection.
https://www.phctrials.ox.ac.uk/principle-trial
The PRIEST Study: Pandemic Respiratory Infection Emergency System Triage. Optimise the triage of people using the emergency care system with suspected respiratory infections during a pandemic.
https://www.sheffield.ac.uk/scharr/sections/hsr/cure/priestpages/priest
Learn More...
Contact the Acute Care Covid Research Team
Email: AcuteCare.Research@ouh.nhs.uk
Tel no.01865 (2) 21764 or (2) 22003 blp 1263
Hibernating Studies
Due to the Covid -19 pandemic these studies were paused to give way to the nationally prioritised urgent public health studies. We are working towards restarting.
ACIT II
Activation of Coagulation and Inflammation in Trauma
http://www.c4ts.qmul.ac.uk/research-programmes/acit
CRYOSTAT 2
Multi-centre, interventional, randomised, un-blinded, parallel controlled trial. The trial will evaluate the effects of early fibrinogen replacement using cryoprecipitate in adults with major traumatic bleeding. https://www.c4ts.qmul.ac.uk/research-programmes/cryostat
The Support Study
Prospective cohort study of proactive palliative care for hospitalised adults at risk of dying: Evaluation of patient outcomes and hospital costs.
RAPID- I Study
Phase IIb, randomised, double-blind, placebo-controlled, multi-centre trial of infliximab with transcriptomic biomarker and mechanism evaluation in patients with acute pancreatitis.
E-MAGED
E-MAGED is an RCT designed to compare the utility of using direct MRCP versus standard care (USS +/- MRCP) in patients in suspected acute gallstone disease who present to the ED and SEU. https://clinicaltrials.gov/ct2/show/NCT03709030
RAIDS
This is a mix method research to find out in-depth studies provide an opportunity to understand how crashes occur and, from this understanding, contribute to the development of safer roads and safer vehicles.
RePHILL Study
A multi-centre randomised controlled trial of pre-hospital blood product administration versus standard care for traumatic haemorrhage.
https://www.ncbi.nlm.nih.gov/pubmed/29193548
The Influenza Study
A comparison of clinical sample collection methods to detect influenza virus and other respiratory pathogens using whole genome sequencing
The ORIF Study
A multicentre randomised controlled trial assessing the mortality, quality of life, and cost effectiveness of operative rib fixation plus supportive management versus supportive management alone for patients with multiple rib fractures requiring ventilator support. https://www.ndorms.ox.ac.uk/clinical-trials/current-trials-and-studies/orif
OCTS study
The creation of and field testing a new rib fracture specific patient reported outcome measure (PROM)
https://www.nottingham.ac.uk/research/groups/orthopaedicsandtrauma/trauma-research/octs.aspx
Abbott Ketones Study
A multicentre, prospective, single-arm comparison of ßhydroxybutyrate levels in capillary versus venous blood in participants with either in DKA or ketosis.
Whiplash Study
This study aims to investigate why some patients develop chronic pain following a whiplash injury and to determine whether nerve inflammation is responsible for the development of chronic pain following injury.
Force Study and Resources
The Force Study
The Forearm Fracture Recovery in Children Evaluation Study. Randomised controlled trial comparing the use of splint vs bandage in wrist buckle fractures in children .
Link to the Force Study website
Video link to the Force Study Information
Link to children's information video:
https://www.child.forceinfo.org.uk/
Link to parent's information video: https://parent.forceinfo.org.uk
REBOA study and resources
UK REBOA TRIAL
Bayesian group-sequential randomised controlled trial, comparing standard major trauma centre treatment plus REBOA with standard major trauma centre treatment alone.
UK REBOA - link to trial site
UK REBOA - Enrol a patient
UK REBOA - narrated presentations
PREVIOUS RESEARCH PROJECTS
CRYOSTAT
Early Cryoprecipitate in major Haemorrhage in Trauma is a randomised open label study to determine whether early administration of cryoprecipitate in bleeding trauma patients is possible .
https://academic.oup.com/bja/article/115/1/76/238264
ECHO
This project aims to address the question of what the potential harm of handover failures along the emergency care pathway is and what common organisational deficiencies impact upon the reliability and quality of handovers. https://core.ac.uk/download/pdf/36771298.pdf
PARAMEDIC
Pre-hospital randomised assessment of mechanical compression device in cardiac arrest. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61886-9/abstract
IPMED
Integrated Patient Monitoring in the Emergency Department.
https://www.ncbi.nlm.nih.gov/pubmed/25055312
SCARTA
A Simple Cognitive task After a Road Traffic Accident.This research study is designed to investigate the effects of a simple cognitive task (a memory reactivation cue following by playing the computer game "Tetris") on flashbacks and other post-traumatic stress symptoms after a road traffic accident.
http://www.ox.ac.uk/news/2017-03-28-tetris-used-prevent-post-traumatic-stress-symptoms
RE_VERSE AD
Evaluate the reversal of the anticoagulant effects of dabigatran by IV administration of 5.0g idarucizumab in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.
http://www.nejm.org/doi/full/10.1056/NEJMoa1502000
ORANGE
Oral Anticoagulant Agent-associated Bleeding Events Reporting System (ORANGE) is an observational study on current management practices and clinical outcomes of OAC-associated major bleeding events across the UK, in order that we may develop better management strategies for the future and provide a knowledge base for further research.
http://www.haematologica.org/content/haematol/103/4/738.full.pdf
MP4OX
Research study to find out if the study drug, MP4OX, given together with standard treatment, is safe and effective in treating severely injured trauma patients with haemorrhagic shock.
EURODEM
European Dyspnoea survey in the Emergency Departments.
ICICLE
A Case Control Study of the Effectiveness of Q/LAIV Versus Inactivated Influenza Vaccine and No Vaccine in Subjects 2-17 Years of Age
VERITY
Ankle sprain injury study using radiological imaging to pre-dict recovery.
SPRAINED
Synthesising a clinical Prognostic Rule of Ankle Injuries in the Emergency Department. This is a cohort study looking at how clinicians might predict which types of ankle sprains and or patient groups have better outcomes.
LEAK
A multicenter prospective cohort study on the diagnostic accuracy of NeutrophilGelatinase-Associated Lipocalin (NGAL) and Cystatin C for Acute Kidney Injury (AKI) inconsecutive adults admitted from the Emergency Department.
POEM
The study aims to assess the adequacy of pain management in patients presenting to the ED with confirmed long bone fracture and/or dislocation isolated to a proximal or distal limb.
AIRWAYS 2
AIRWAYS-2 is a randomised trial which is comparing the clinical and cost effectiveness of the i-gel supraglottic airway device with tracheal intubation in the initial airway management of patients who have suffered an out of hospital cardiac arrest (OHCA).
https://jamanetwork.com/journals/jama/article-abstract/2698493
PARAMEDIC 2
The PARAMEDIC2 trial is looking at whether adrenaline is helpful or harmful in the treatment of cardiac arrest which occurs outside of hospital. Answering this question will help to improve future treatment of people who have a cardiac arrest.
https://www.nejm.org/doi/full/10.1056/NEJMoa1806842
AUSTERITY IN HEALTHCARE - UK
The aim of our study is to develop an understanding of how austerity-driven policies and subsequent system reforms impact and shape ideas and practices of ethical professional conduct.
SNAP 2
The 2nd Sprint National Anaesthesia Project: Epidemiology of Critical Care provision after Surgery (SNAP-2: EpiCCS)is an epidemiology study of perioperative risk and outcome, and critical care referral and admission after inpatient surgery in the UK.
ENCEPH UK
The study aims to determine the early clinical features predictive of Herpes simplex virus (HSV) encephalitis to support the development of a predictive tool for HSV encephalitis based on these early clinical features.
RAMPP
Multi-centre randomised controlled trial comparing ambulatory management to standard care ( aspiration +/- standard chest drain insertion) with an observational cohort study of patients not requiring an intervention. https://bmjopenrespres.bmj.com/content/6/1/e000403
THE AWARD STUDY
Observational cohort study to study and understand the characteristics of patients with acute exacerbations of airway disease (asthma, COPD and overlap) presenting to the ED.
E- FiT
A multi-centre, randomised, double blind, placebo controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage.
i - TACTIC
A multi-centre, prospective, randomized controlled study to compare outcomes of viscoelastic haemostatic assay (VHA)-guided resuscitation versus optimised conventional coagulation test resuscitation support in haemorrhaging trauma patients.
NOPAC
A randomised controlled trial of topical intranasal tranexamic acid versus placebo in patients presenting to the Emergency Department with spontaneous acute epistaxis.
Hi-SPEC
Multicentre, UK, open label, randomised controlled trial to establish the efficacy of Heimlich valves in the management of secondary spontaneous pneumothorax.
CAP -IT
Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial.
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RECENT PUBLICATIONS
Russell, REK & Doggett, T & Pavord, I & Pullinger, Richard & Beer, S & Bafadhel, M. (2016). S68 Copd in the ed: eosinophils, treatment and outcomes, data from the pre-award study. Thorax. 71. A40.2-A41.
Clifton, David & Wong, David & Fleming, Susannah & J. Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2011). Novelty Detection for Identifying Deterioration in Emergency Department Patients. 6936. 220-227
Pullinger, Richard & Wilson, Sarah & Way, Rob & Santos, Mauro & Wong, David & Clifton, David & Birks, Jacqueline & Tarassenko, L. (2016). Implementing an electronic observation and early warning score chart in the emergency department: A feasibility study. European Journal of Emergency Medicine. 24.
Way, R & Warnes, K & Yousefi, S & Beer, S & Santos, M & Wong, David & Wilson, S & Pullinger, Richard & Tarassenko, Lionel. (2014). Paper and electronic early warning scoring systems: review of 6000 patients in the emergency department. International Emergency Nursing. 22. 259-259.
J Wilson, Sarah & Wong, David & Pullinger, Richard & Way, Rob & Clifton, David & Tarassenko, L. (2014). Analysis of a data-fusion system for continuous vital sign monitoring in an emergency department. European Journal of Emergency Medicine. 23
Clifton, David & Wong, David & Clifton, Lei & Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2013). A Large-Scale Clinical Validation of an Integrated Monitoring System in the Emergency Department. Biomedical and Health Informatics, IEEE Journal of Biomedical and Health Informatics. 17. 835-842. 10.1109/JBHI.2012.2234130.
J Wilson, Sarah & Wong, David & Clifton, David & Fleming, Susannah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2012). Track and trigger in an emergency department: An observational evaluation study. Emergency medicine journal 30.
Clifton, David & Wong, David & Fleming, Susannah & J. Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2011). Novelty Detection for Identifying Deterioration in Emergency Department Patients. 6936. 220-227.
Curry, N & Raja, A & Hughes, T & Black, J & Pullinger, Richard & Davenport, Ross & Brohi, Karim & Stanworth, S. (2010). A prospective observational study evaluating changes in coagulation parameters in trauma admissions. 50th Annual Scientific Meeting of the British-Society-for-Haematology, Volume: 149 1010.
Keating, L & Benger, Jonathan & Beetham, Robert & Bateman, S & Veysey, S & Kendall, J & Pullinger, Richard. (2006). The PRIMA Study: Presentation ischaemia-modified albumin in the emergency department. Emergency Medicine Journal 23. 764-8. 10.1136/emj.2006.036269.
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