ACIT II

The Support Study

CRYOSTAT 2

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Activation of Coagulation and Inflammation in Trauma 

http://www.c4ts.qmul.ac.uk/research-programmes/acit



CRYOSTAT 2

The Support Study

CRYOSTAT 2

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Multi-centre, interventional, randomised, un-blinded, parallel controlled trial. The trial will evaluate the effects of early fibrinogen replacement using cryoprecipitate in adults with major traumatic bleeding.  https://www.c4ts.qmul.ac.uk/research-programmes/cryostat 



The Support Study

The Support Study

The Support Study

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Prospective cohort study of proactive  palliative care for hospitalised adults at risk of dying: Evaluation of patient outcomes and hospital costs. 

RAPID- I Study

RAPID- I Study

The Support Study

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Phase IIb, randomised, double-blind, placebo-controlled, multi-centre trial of infliximab with transcriptomic biomarker and mechanism evaluation in patients with acute pancreatitis.  

http://rapid-one.org.uk/

 

E-MAGED

RAPID- I Study

E-MAGED

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E-MAGED is an RCT designed to compare the utility of using direct MRCP versus standard care (USS +/- MRCP) in patients in suspected acute gallstone disease who present to the ED and SEU. https://clinicaltrials.gov/ct2/show/NCT03709030




RAIDS

RAPID- I Study

E-MAGED

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This is a mix method research to find out in-depth studies provide an opportunity to understand how crashes occur and, from this understanding, contribute to the development of safer roads and safer vehicles.   

https://trl.co.uk/projects/road-accident-depth-study-raids 

BioAID

The Influenza Study

The GAINS -2 Study

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BioAID is a multi-centre research tissue bank  to enable observational studies in adult infectious diseases.  

https://www.ucl.ac.uk/infection-immunity/research/research-department-infection/lab-research-groups/infection-clinical-research-hub/portfolio 

The GAINS -2 Study

The Influenza Study

The GAINS -2 Study


The GAINS-2 Study

The GAinS investigators: application of an integrated immune -omic approach in sepsis 


The Influenza Study

The Influenza Study

The Influenza Study

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A comparison of clinical sample collection methods to detect influenza virus and other respiratory pathogens using whole genome sequencing
 


The ORIF Study

Abbott Ketones Study

The Influenza Study

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A multicentre randomised controlled trial assessing the mortality, quality of life, and cost effectiveness of operative rib fixation plus supportive management versus supportive management alone for patients with multiple rib fractures requiring ventilator support.    https://www.ndorms.ox.ac.uk/clinical-trials/current-trials-and-studies/orif 

OCTS study

Abbott Ketones Study

Abbott Ketones Study

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The creation of and field testing a new rib fracture specific patient reported outcome measure (PROM)  

https://www.nottingham.ac.uk/research/groups/orthopaedicsandtrauma/trauma-research/octs.aspx

Abbott Ketones Study

Abbott Ketones Study

Abbott Ketones Study

Abbott Ketones Study

A multicentre, prospective, single-arm comparison of ßhydroxybutyrate levels in capillary versus venous blood in participants with either in DKA or ketosis. 


RePHILL

RePHILL

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RePHILL

RePHILL

RePHILL

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A Multi-Centre Randomised Controlled Trial of Pre-Hospital Blood Product Administration versus Standard Care for Traumatic Haemorrhage 


 https://www.birmingham.ac.uk/research/bctu/trials/portfolio-v/Rephill/index.aspx 

RePHILL

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The PAINTED Study

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Pandemic Influenza Triage in the Emergency Department

We aim to identify the most accurate triage method for predicting severe illness among patients attending the emergency department with suspected pandemic influenza.

CRYOSTAT

PARAMEDIC

CRYOSTAT

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Early Cryoprecipitate in major Haemorrhage in Trauma is a randomised open label study to determine whether early administration of cryoprecipitate in bleeding trauma patients is possible .

https://academic.oup.com/bja/article/115/1/76/238264




ECHO

PARAMEDIC

CRYOSTAT

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This project aims to address the question of what the potential harm of handover failures along the emergency care pathway is and what common organisational deficiencies impact upon the reliability and quality of handovers. https://core.ac.uk/download/pdf/36771298.pdf

PARAMEDIC

PARAMEDIC

PARAMEDIC

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Pre-hospital randomised assessment of mechanical compression device in cardiac arrest. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61886-9/abstract






IPMED

RE_VERSE AD

PARAMEDIC

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Integrated Patient Monitoring in the Emergency Department.

https://www.ncbi.nlm.nih.gov/pubmed/25055312





SCARTA

RE_VERSE AD

RE_VERSE AD

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A Simple Cognitive task  After a Road Traffic Accident.This research study is designed to investigate the effects of a simple cognitive task (a memory reactivation cue following by playing the computer game "Tetris") on flashbacks and other post-traumatic stress symptoms after a road traffic accident. 

http://www.ox.ac.uk/news/2017-03-28-tetris-used-prevent-post-traumatic-stress-symptoms

RE_VERSE AD

RE_VERSE AD

RE_VERSE AD

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Evaluate the reversal of the anticoagulant effects of dabigatran by IV administration of 5.0g idarucizumab in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.  

 http://www.nejm.org/doi/full/10.1056/NEJMoa1502000





ORANGE

ORANGE

ORANGE

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Oral Anticoagulant Agent-associated Bleeding Events Reporting System (ORANGE) is an observational study on current management practices and clinical outcomes of OAC-associated major bleeding events across the UK, in order that we may develop better management strategies for the future and provide a knowledge base for further research.

http://www.haematologica.org/content/haematol/103/4/738.full.pdf

MP4OX

ORANGE

ORANGE

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Research study to find out if the study drug, MP4OX, given together with standard treatment, is safe and effective in treating severely injured trauma patients with haemorrhagic shock.



EURODEM

ORANGE

EURODEM

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European Dyspnoea survey in the Emergency Departments.






ICICLE

SPRAINED

EURODEM

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A Case Control Study of the Effectiveness of Q/LAIV Versus Inactivated Influenza Vaccine and No Vaccine in Subjects  2-17 Years of Age




VERITY

SPRAINED

SPRAINED

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Ankle sprain injury study using radiological imaging to pre-dict recovery.





SPRAINED

SPRAINED

SPRAINED

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Synthesising a clinical Prognostic Rule of Ankle Injuries in the Emergency Department. This is a cohort study looking  at how clinicians might predict which types of ankle sprains and or patient groups  have better outcomes.


LEAK

AIRWAYS 2

LEAK

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A multicenter prospective cohort study on the diagnostic accuracy of NeutrophilGelatinase-Associated Lipocalin (NGAL) and Cystatin C for Acute Kidney Injury (AKI) inconsecutive adults admitted from the Emergency Department.

POEM

AIRWAYS 2

LEAK

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The study aims to assess the adequacy of pain management in patients presenting to the ED with confirmed long bone fracture and/or dislocation isolated to a proximal or distal limb.




AIRWAYS 2

AIRWAYS 2

PARAMEDIC 2

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AIRWAYS-2 is a randomised trial which is comparing the clinical and cost effectiveness of the i-gel supraglottic airway device with tracheal intubation in the initial airway management of patients who have suffered an out of hospital cardiac arrest (OHCA).

https://jamanetwork.com/journals/jama/article-abstract/2698493



PARAMEDIC 2

AUSTERITY IN HEALTHCARE - UK

PARAMEDIC 2

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The PARAMEDIC2 trial is looking at whether adrenaline is helpful or harmful in the treatment of cardiac arrest which occurs outside of hospital. Answering this question will help to improve future treatment of people who have a cardiac arrest.

https://www.nejm.org/doi/full/10.1056/NEJMoa1806842


AUSTERITY IN HEALTHCARE - UK

AUSTERITY IN HEALTHCARE - UK

AUSTERITY IN HEALTHCARE - UK

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The aim of our study is to develop an understanding of how austerity-driven policies and subsequent system reforms impact and shape ideas and practices of ethical professional conduct.

SNAP 2

AUSTERITY IN HEALTHCARE - UK

AUSTERITY IN HEALTHCARE - UK

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The 2nd Sprint National Anaesthesia Project: Epidemiology of Critical Care provision after Surgery (SNAP-2: EpiCCS)is an epidemiology study of perioperative risk and outcome, and critical care referral and admission after inpatient surgery in the UK.

ENCEPH UK

THE AWARD STUDY

ENCEPH UK

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The study aims to determine the early clinical features predictive of Herpes simplex virus (HSV) encephalitis to support the development of a predictive tool for HSV encephalitis based on these early clinical features.




RAMPP

THE AWARD STUDY

ENCEPH UK

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Multi-centre randomised controlled trial comparing ambulatory management to standard care ( aspiration +/- standard chest drain insertion) with an observational cohort study of patients not requiring an intervention. https://bmjopenrespres.bmj.com/content/6/1/e000403 

THE AWARD STUDY

THE AWARD STUDY

THE AWARD STUDY

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Observational cohort study  to study and understand the characteristics of patients with acute exacerbations of airway disease (asthma, COPD and overlap) presenting to the ED.


E- FiT

i - TACTIC

THE AWARD STUDY

A multi-centre, randomised, double blind, placebo controlled trial evaluating the effects of early a

A multi-centre, randomised, double blind, placebo controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage.

i - TACTIC

i - TACTIC

i - TACTIC

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A multi-centre, prospective, randomized controlled study to compare outcomes of viscoelastic haemostatic assay (VHA)-guided resuscitation versus optimised conventional coagulation test resuscitation support in haemorrhaging trauma patients.


NOPAC

i - TACTIC

i - TACTIC

A randomised controlled trial of topical intranasal tranexamic acid versus placebo in patients presenting to the Emergency Department with spontaneous acute epistaxis.

Hi-SPEC

Hi-SPEC

Hi-SPEC

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Multicentre, UK, open label, randomised controlled trial to establish the efficacy of Heimlich valves in the management of secondary spontaneous pneumothorax.

CAP -IT

Hi-SPEC

Hi-SPEC

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Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial.

GP ED

Hi-SPEC

GP ED

A mixed method study looking at the  impact of GPs working in or alongside the ED (GPED) on patient

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GP ED

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Russell, REK & Doggett, T & Pavord, I & Pullinger, Richard & Beer, S & Bafadhel, M. (2016). S68 Copd in the ed: eosinophils, treatment and outcomes, data from the pre-award study. Thorax. 71. A40.2-A41.  

Clifton, David & Wong, David & Fleming, Susannah & J. Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2011). Novelty Detection for Identifying Deterioration in Emergency Department Patients. 6936. 220-227

Pullinger, Richard & Wilson, Sarah & Way, Rob & Santos, Mauro & Wong, David & Clifton, David & Birks, Jacqueline & Tarassenko, L. (2016). Implementing an electronic observation and early warning score chart in the emergency department: A feasibility study. European Journal of Emergency Medicine. 24. 

Way, R & Warnes, K & Yousefi, S & Beer, S & Santos, M & Wong, David & Wilson, S & Pullinger, Richard & Tarassenko, Lionel. (2014). Paper and electronic early warning scoring systems: review of 6000 patients in the emergency department. International Emergency Nursing. 22. 259-259. 

J Wilson, Sarah & Wong, David & Pullinger, Richard & Way, Rob & Clifton, David & Tarassenko, L. (2014). Analysis of a data-fusion system for continuous vital sign monitoring in an emergency department. European Journal of  Emergency Medicine. 23 

Clifton, David & Wong, David & Clifton, Lei & Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2013). A Large-Scale Clinical Validation of an Integrated Monitoring System in the Emergency Department. Biomedical and Health Informatics, IEEE Journal of Biomedical and Health Informatics. 17. 835-842. 10.1109/JBHI.2012.2234130. 

J Wilson, Sarah & Wong, David & Clifton, David & Fleming, Susannah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2012). Track and trigger in an emergency department: An observational evaluation study. Emergency medicine journal  30.

Clifton, David & Wong, David & Fleming, Susannah & J. Wilson, Sarah & Way, Rob & Pullinger, Richard & Tarassenko, L. (2011). Novelty Detection for Identifying Deterioration in Emergency Department Patients. 6936. 220-227. 

Curry, N & Raja, A & Hughes, T & Black, J & Pullinger, Richard & Davenport, Ross & Brohi, Karim & Stanworth, S. (2010). A prospective observational study evaluating changes in coagulation parameters in trauma admissions.  50th Annual Scientific Meeting of the British-Society-for-Haematology, Volume: 149 1010. 

Keating, L & Benger, Jonathan & Beetham, Robert & Bateman, S & Veysey, S & Kendall, J & Pullinger, Richard. (2006). The PRIMA Study: Presentation ischaemia-modified albumin in the emergency department. Emergency Medicine Journal  23. 764-8. 10.1136/emj.2006.036269. 

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